合作类型：技术 行业类别: 医药研发 英国  过期时间：2017年05月17日   

一家英国的生物技术公司提供无版权费的人类化抗体服务。该公司有超过13年的抗体综合开发经验以及自己的专利软件平台进行健康的、迅速的和准确的现代CDR移植技术。该公司正在寻找合作伙伴进行技术协助下的商业合作或者技术合作。

英语原文：

Summary:

A UK biotechnology company is offering royalty free antibody humanization services. The company uses a combination of 13+ years experience in the antibody development industry and their own patented software platform to perform a robust, rapid and accurate modernized version of the traditional CDR grafting technique.  They are seeking commercial agreements with technical assistance or technical cooperation agreements

Details:

The company provides royalty free antibody humanization of monoclonal antibodies. Using their next generation insilico CDRx technology they have modernized the traditional Complementarity Determining Region (CDR) grafting technique.

They identify and combine the essential sequences from antibody variable domains into human donor sequences (not germ line) to create a panel of full length humanized antibodies for expression.

Fully humanized monoclonal antibodies are an essential step in the progression of a drug to the clinic and the company's in-house expertise ensures its success.  3, 4 or 5 Vh and Vl sequences can be designed, which gives 9,16 or 25 humanized variant combinations respectively. The more humanized sequences a client opts to design, the more flexibility they will have in choosing a lead candidate with the specific features required.

Affinity is guaranteed within a 2-fold range of the parental antibody (with 16 variants tested by Biacore).  The company produces a chimeric antibody at the same time to act as a control and their CDRx process has so far yielded a 100% success rate.

Type and Role of Partners Sought:

The company is looking for partners who have produced murine (rodent family) antibodies and are now seeking humanization of these products as a step towards clinical approvals and marketing.

Cooperation may take the form of a commercial agreement with technical assistance or could also be in the form of a technical cooperation agreement.